Browsing by Author "Chen, Zhilei"
Now showing items 1-20 of 23
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Low, AlyssaClostridioides difficile (C. difficile), the microbe responsible for Clostridioides difficile infection (CDI), is a common nosocomial infection that exerts its pathogenicity primarily by two toxins, TcdA and TcdB. Designed ...
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Chamoun Emanuelli, Ana M (2014-08-06)Hepatitis C virus (HCV), Human Immunodeficiency virus (HIV) and Herpes Simplex virus (HSV) are pathogenic viruses known to cause liver disorder, acquired immunodeficiency and skin lesions, respectively. Although current ...
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Wang, Hai (2018-12-03)This dissertation focuses on the development of advanced synthetic methodologies to afford well-defined polyphosphoramidates (PPAs) containing acid-labile backbone linkages (phosphoramidate). By applying these methodologies, ...
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Klemashevich, Cory (2013-05-09)Up to 170 million people are infected with Hepatitis C Virus worldwide. Chronic HCV infection is the leading cause of fibrosis, cirrhosis and liver cancer. Treatment options are currently limited to interferon based ...
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Becerra-Bayona, Silvia M. (2013-07-25)Mesenchymal stem cell (MSC) differentiation is known to be influenced by a range of environmental stimuli. MSC-based bone regeneration strategies would benefit from the identification of scaffold material properties which ...
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Engineering Escherichia coli to Control Biofilm Formation, Dispersal, and Persister Cell Formation Hong, Seok Hoon (2012-02-14)Biofilms are formed in aquatic environments by the attachment of bacteria to submerged surfaces, to the air/liquid interface, and to each other. Although biofilms are associated with disease and biofouling, the robust ...
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Sanchez Torres, Viviana (2012-02-14)Escherichia coli is the best characterized bacterium; it grows rapidly, and it is easy to manipulate genetically. An increased knowledge about the physiology of this model organism will facilitate the development of ...
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Huang, Mian (2012-10-19)Many drug-resistant mechanisms in Candida albicans (C. albicans), a clinical important fungal pathogen, have been well characterized. However, few studies investigated the emergence of drug resistance from the evolutionary ...
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Guo, Yuqi (2017-07-27)Industrial biotechnology provides a sustainable and environmentally sound way to produce chemicals by using renewable raw materials. Sustainability of industrial biotechnology can be further improved if alternative water ...
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Ramirez, Miguel Angel (2013-11-26)Inteins are proteins encoded within a precursor gene that excise themselves after translation and ligate the surrounding proteins with a peptide bond. Since their discovery two decades ago, many inteins have been engineered ...
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Chen, Zhilei; Ramirez, Miguel A.; Guan, Dongli (United States. Patent and Trademark Office; Texas A&M University. Libraries, 2018-10-02)The present invention includes methods, compositions, uses, and kits for purifying a protein of interest (POI) comprising contacting a first fusion protein comprising the POI fused to the C-terminus of an intein C-fragment ...
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Kim, Dae Nyun (2012-10-19)There are approximately 10^14 bacteria belonging to nearly 1000 different species in the human gastrointestinal (GI) tract that co-exist with host cells. Within the GI tract, signaling molecules secreted by both eukaryotic ...
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Kohli, Nandita (2017-05-05)The microbial community present in the gastrointestinal tract is an important component of the host defense against pathogen infections. Prior work from our lab demonstrated that indole, a microbial metabolite of tryptophan, ...
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Valdes, Najla (2012-04-20)A protease-free, column-free protein purification technology was developed through a combination of an engineered thio-responsive split-intein and a stimulus-responsive elastin-like polypeptide (ELP). The DnaE split intein ...
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Winkler, James (2014-04-16)Adaptive laboratory evolution (ALE) is a powerful tool for strain improvement, and has been applied successfully to improve a range of desirable phenotypes in model organisms through continuous cultivation under a selective ...
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Chamoun-Emanuelli, Ana; Pecheur, Eve-Isabelle; Simeon, Rudo; Huang, Da; Cremer, Paul; Chen, Zhilei (Antimicrobial Agents and Chemotherapy, 2013)
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Simeon, Rudo L.; Chen, Zhilei (PLoS, 2013-12-31)Genetic suppressor elements (GSEs) are biomolecules derived from a gene or genome of interest that act as transdominant inhibitors of biological functions presumably by disruption of critical biological interfaces. We ...
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Simeon, Rudo Lyndon (2013-12-12)Hepatitis C virus (HCV) currently affects ~5% of the world’s population and has relatively limited treatment options for infected patients. Genetic suppressor elements (GSE) derived from a gene or genome of interest can ...
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Huang, Da (2013-11-14)Our laboratory has previously invented and characterized a technique for studying ligand-receptor interactions on supported lipid bilayers (SLBs) without fluorescently labeled analytes. This technique utilizes a pH-sensitive ...
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Choi, Kyungoh (2013-07-17)The overall goal of this research is to understand roles of gut microbiota metabolites and adipocyte transcription factor (TF) network in health and disease by developing systematic analysis methods. As microbiota can ...